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single-pass tangential flow filtration  (Sanofi)

 
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    Sanofi single-pass tangential flow filtration
    Single Pass Tangential Flow Filtration, supplied by Sanofi, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/single-pass+tangential+flow+filtration/single+pass+tangential+flow+filtration/10__1016_slash_j__memsci__2023__121633-11-63-44
    Average 90 stars, based on 1 article reviews
    single-pass tangential flow filtration - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Control:

    Article Title: Design of a process development workflow and control strategy for single-pass tangential flow filtration and implementation for integrated and continuous biomanufacturing
    Article Snippet: .. Design of a process development workflow and control strategy for single-pass tangential flow filtration and implementation for integrated and continuous biomanufacturing Shashi Malladi *, Michael J. Coolbaugh, Crystal Thomas, Sushmitha Krishnan, Chad T. Varner, Jason Walther, Kevin P. Brower Mammalian Platform, Global CMC Development, Sanofi, Framingham, MA, 01701, USA A R T I C L E I N F O Keywords: Integrated and continuous biomanufacturing Single-pass tangential flow filtration Robust control Commercial-scale Biologics A B S T R A C T Integrated and continuous biomanufacturing (ICB) offers several advantages compared to traditional batch methods, prompting the development of novel technologies and infrastructure for the implementation of ICB in the biopharmaceutical sector. ..

    Filtration:

    Article Title: Design of a process development workflow and control strategy for single-pass tangential flow filtration and implementation for integrated and continuous biomanufacturing
    Article Snippet: .. Design of a process development workflow and control strategy for single-pass tangential flow filtration and implementation for integrated and continuous biomanufacturing Shashi Malladi *, Michael J. Coolbaugh, Crystal Thomas, Sushmitha Krishnan, Chad T. Varner, Jason Walther, Kevin P. Brower Mammalian Platform, Global CMC Development, Sanofi, Framingham, MA, 01701, USA A R T I C L E I N F O Keywords: Integrated and continuous biomanufacturing Single-pass tangential flow filtration Robust control Commercial-scale Biologics A B S T R A C T Integrated and continuous biomanufacturing (ICB) offers several advantages compared to traditional batch methods, prompting the development of novel technologies and infrastructure for the implementation of ICB in the biopharmaceutical sector. ..

    CMC:

    Article Title: Design of a process development workflow and control strategy for single-pass tangential flow filtration and implementation for integrated and continuous biomanufacturing
    Article Snippet: .. Design of a process development workflow and control strategy for single-pass tangential flow filtration and implementation for integrated and continuous biomanufacturing Shashi Malladi *, Michael J. Coolbaugh, Crystal Thomas, Sushmitha Krishnan, Chad T. Varner, Jason Walther, Kevin P. Brower Mammalian Platform, Global CMC Development, Sanofi, Framingham, MA, 01701, USA A R T I C L E I N F O Keywords: Integrated and continuous biomanufacturing Single-pass tangential flow filtration Robust control Commercial-scale Biologics A B S T R A C T Integrated and continuous biomanufacturing (ICB) offers several advantages compared to traditional batch methods, prompting the development of novel technologies and infrastructure for the implementation of ICB in the biopharmaceutical sector. ..



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    Image Search Results


    FIGURE 1 | Schematic of integrated SPTFF and HPCMP processes for CCF concentration and HCP removal.

    Journal: Biotechnology and bioengineering

    Article Title: Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing.

    doi: 10.1002/bit.29038

    Figure Lengend Snippet: FIGURE 1 | Schematic of integrated SPTFF and HPCMP processes for CCF concentration and HCP removal.

    Article Snippet: Brinkmann and Elouafiq (2021) used single‐pass tangential flow filtration (SPTFF) for the inline concentration of CCF for several mAbs, with the preconcentration reducing the consumption of Protein A resin by as much as 80% in short fed‐batch campaigns and enabling longer column lifetimes in continuous (perfusion) processes.

    Techniques: Concentration Assay

    FIGURE 6 | SEC chromatograms (top) of the initial feed, the 20x concentrated material obtained by SPTFF, and the retentate product obtained after HPCMP (after 12 h of operation). Bottom panel shows an expanded view of the region containing HCP. The UV absorbance has in each case been normalized by the mAb concentration in that sample as determined by analytical Protein A chromatography.

    Journal: Biotechnology and bioengineering

    Article Title: Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing.

    doi: 10.1002/bit.29038

    Figure Lengend Snippet: FIGURE 6 | SEC chromatograms (top) of the initial feed, the 20x concentrated material obtained by SPTFF, and the retentate product obtained after HPCMP (after 12 h of operation). Bottom panel shows an expanded view of the region containing HCP. The UV absorbance has in each case been normalized by the mAb concentration in that sample as determined by analytical Protein A chromatography.

    Article Snippet: Brinkmann and Elouafiq (2021) used single‐pass tangential flow filtration (SPTFF) for the inline concentration of CCF for several mAbs, with the preconcentration reducing the consumption of Protein A resin by as much as 80% in short fed‐batch campaigns and enabling longer column lifetimes in continuous (perfusion) processes.

    Techniques: Concentration Assay, Chromatography

    FIGURE 7 | Coomassie blue SDS‐PAGE gel image. M is the protein ladder. 1 = original feed (before the flux stepping experiment). 2 = SPTFF feed (during the 20x concentration). 3 = SPTFF permeate. 4 = HPCMP feed (dilution 1:20). 5 = HPCMP draw solution after 12 h. 6 = HPCMP product after 12 h (dilution 1:20). 7 = HPCMP draw solution after 36 h. 8 = HPCMP product after 36 h (dilution 1:20). Loading volume for 1 is 3 µL; for 2, 4, 6, and 8 is 5 µL; and for 3, 5, and 7 is 20 µL.

    Journal: Biotechnology and bioengineering

    Article Title: Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing.

    doi: 10.1002/bit.29038

    Figure Lengend Snippet: FIGURE 7 | Coomassie blue SDS‐PAGE gel image. M is the protein ladder. 1 = original feed (before the flux stepping experiment). 2 = SPTFF feed (during the 20x concentration). 3 = SPTFF permeate. 4 = HPCMP feed (dilution 1:20). 5 = HPCMP draw solution after 12 h. 6 = HPCMP product after 12 h (dilution 1:20). 7 = HPCMP draw solution after 36 h. 8 = HPCMP product after 36 h (dilution 1:20). Loading volume for 1 is 3 µL; for 2, 4, 6, and 8 is 5 µL; and for 3, 5, and 7 is 20 µL.

    Article Snippet: Brinkmann and Elouafiq (2021) used single‐pass tangential flow filtration (SPTFF) for the inline concentration of CCF for several mAbs, with the preconcentration reducing the consumption of Protein A resin by as much as 80% in short fed‐batch campaigns and enabling longer column lifetimes in continuous (perfusion) processes.

    Techniques: SDS Page, Concentration Assay